L-墨蝶呤

生物活性靶点体外研究体内研究 L-墨蝶呤试剂级价格

L-墨蝶呤

CAS号:17094-01-8
英文名:L-SEPIAPTERIN
中文名:L-墨蝶呤
CBNumber:CB0116110
分子式:C9H11N5O3
分子量:237.22
MOL File:17094-01-8.mol

L-墨蝶呤化学性质

熔点 :>270 °C (dec.)
沸点 :448.1±55.0 °C(Predicted)
密度 :1.86±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :DMSO: 27 mg/mL
形态 :solid
酸度系数(pKa) :12.33±0.20(Predicted)
颜色 :yellow
稳定性 :Light Sensitive
CAS 数据库 :17094-01-8

安全信息

安全说明 :24/25
WGK Germany :3

L-墨蝶呤性质、用途与生产工艺

生物活性 L-Sepiapterin (Sepiapterin) 是内皮型一氧化氮合酶 (eNOS) 辅因子四氢生物喋呤 (BH4) 的前体。L-Sepiapterin 改善 db/db 小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin 通过下调 p70S6K 依赖性 VEGFR-2 表达抑制卵巢癌细胞增殖和迁移。
靶点

Human Endogenous Metabolite

体外研究

L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70 ^S6K .
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.

Cell Proliferation Assay

Cell Line:	SKOV-3 cells
Concentration:	0.1, 1, 10 μM
Incubation Time:	24 hours
Result:	Induced cell proliferation in a dose-dependent manner.

体内研究

Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.

Animal Model:	Male C57BL/KsJ diabetic mice (db/db)
Dosage:	10 mg/kg
Administration:	P.o. (powder chow); daily for or 8 weeks
Result:	Significantly improved the relaxation to Ach in SMA from db/db mice.