27-羟基胆固醇

简介生物活性靶点体外研究 27-羟基胆固醇试剂级价格

27-羟基胆固醇

CAS号:20380-11-4
英文名:27-Hydroxycholesterol
中文名:27-羟基胆固醇
CBNumber:CB01117046
分子式:C27H46O2
分子量:402.65
MOL File:20380-11-4.mol

27-羟基胆固醇化学性质

熔点 :172-174 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
沸点 :517.1±23.0 °C(Predicted)
密度 :1.03
储存条件 :-20°
溶解度 :Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
形态 :White solid.
酸度系数(pKa) :15.03±0.70(Predicted)
颜色 :White
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

27-羟基胆固醇性质、用途与生产工艺

简介
27-羟基胆固醇是一种内源性的氧化胆固醇，有着多重生物学功能，包括选择性雌激素受体调节物（SERM）活性，肝X受体（LXR）激动剂等，由细胞色素P450氧化酶CYP27A1催化胆固醇生成。
生物活性 27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
靶点

Human Endogenous Metabolite
体外研究

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload.