吡啶-3-乙炔
- CAS号:120241-79-4
- 英文名:Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)
- 中文名:吡啶-3-乙炔
- CBNumber:CB01069415
- 分子式:C7H6N4
- 分子量:146.15
- MOL File:120241-79-4.mol
- 熔点 :180-182 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
- 沸点 :386.6±17.0 °C(Predicted)
- 密度 :1.296±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :7.54±0.70(Predicted)
- 颜色 :White to off-white
- 海关编码 :2933998090
吡啶-3-乙炔性质、用途与生产工艺
- 生物活性 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) 是SIRT3的选择性抑制剂，相对于Sirt1和Sirt2来说，对Sirt3具有较高选择性。对SIRT1、SIRT2、SIRT3的IC50分别为88 nM、92 nM、16 nM。
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靶点
Target Value SIRT3
(cell-free)16 nM SIRT1
(cell-free)88 nM SIRT2
(cell-free)92 nM -
体外研究
在暴露于镉的HepG2细胞中，3-TYP可减弱由褪黑色素诱导的去乙酰化SOD2表达增加及抑制SOD2活性。
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体内研究
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
- 更新日期：2024/11/08
- 产品编号：HY-108331
- 产品名称：吡啶-3-乙炔 3-TYP
- CAS编号：120241-79-4
- 包装：5mg
- 价格：600元
- 更新日期：2024/11/08
- 产品编号：HY-108331
- 产品名称：吡啶-3-乙炔 3-TYP
- CAS编号：120241-79-4
- 包装：10mM * 1mLin DMSO
- 价格：660元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
