3,4-苯并芘标准溶液

简介危害生物活性体内研究 3,4-苯并芘标准溶液试剂级价格

3,4-苯并芘标准溶液

CAS号:50-32-8
英文名:Benzo[a]pyrene
中文名:3,4-苯并芘标准溶液
CBNumber:CB00135812
分子式:C20H12
分子量:252.31
MOL File:50-32-8.mol

3,4-苯并芘标准溶液化学性质

熔点 :177-180°C
沸点 :495°C
密度 :1.1549 (estimate)
蒸气压 :2.4 at 25 °C (McVeety and Hites, 1988)
折射率 :1.8530 (estimate)
闪点 :495°C
储存条件 :2-8°C
溶解度 :Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983)
形态 :Crystalline
酸度系数(pKa) :>15 (Christensen et al., 1975)
颜色 :Pale yellow/green/orange
水溶解性 :Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water
Merck :14,1103
BRN :1911333
Henry's Law Constant :7.35 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)(x 10^-10 mmHg at 25 °C):
暴露限值 :OSHA: TWA 0.2 mg/m3
稳定性 :Stable. Incompatible with strong oxidizing agents.
InChIKey :FMMWHPNWAFZXNH-UHFFFAOYSA-N
CAS 数据库 :50-32-8(CAS DataBase Reference)
(IARC)致癌物分类 :1 (Vol. Sup 7, 92, 100F) 2012
EPA化学物质信息 :Benzo[a]pyrene (50-32-8)

安全信息

危险品标志 :T,N,F
危险类别码 :45-46-50/53-60-61-43-67-66-36-11-65-38-52/53-36/37/38
安全说明 :45-53-61-60-26-62-16
危险品运输编号 :2811
WGK Germany :3
RTECS号 :DJ3675000
TSCA :Yes
危险等级 :6.1
包装类别 :III
海关编码 :29029090
毒害物质数据 :50-32-8(Hazardous Substances Data)
毒性 :LD₅₀ for mice (intraperitoneal) 232 mg/kg (Salamone, 1981).

3,4-苯并芘标准溶液 MSDS

3,4-苯并芘标准溶液

3,4-苯并芘标准溶液性质、用途与生产工艺

简介
苯并芘（Benzopyrene），它是由一个苯环和一个芘分子结合而成的多环芳烃类化合物，是一种常见的高活性间接致癌物，是目前世界三大强致癌物之一。根据国家《食用植物油卫生标准》，食用油中苯并芘含量的最高上限为10微克/千克。苯并[a]芘是一种具有潜在的致癌、致畸和致突变作用的5环结构多环芳烃。
危害苯并(a)芘是世界公认的强致癌性多环芳烃污染物，这是因为其自身具有五环结构，因此能积累在生物体中，导致生物染色体发生畸变，无序合成DNA，进而威胁到人类健康。苯并(a)芘在环境中分布很广。
生物活性 Benzo[a]pyrene 在动物模型中显示肺致癌性，并且它们经常用于化学预防研究。
体内研究

Statistically significant decrease is observed at 7 weeks in females receiving 1.0 mg Benzo[a]pyrene (B[a]P) compare with the vehicle group. As lung tumorigenesis induced by Benzo[a]pyrene is dose dependent in female A/J mice. The incidence of hyperplasia values in females treating with 0.25, 0.50, and 1.0 mg Benzo[a]pyrene are significantly higher than in the vehicle-treated group. The incidence of adenoma in females receiving 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of adenoma in the group treated with 1.0 mg is also significantly higher than in the vehicle group. The incidences of hyperplasia and adenoma in female A/J mice are significantly increased by Benzo[a]pyrene in a dose-dependent manner. Benzo[a]pyrene induces an average of 9.38±1.75 tumors with an average tumor load of 19.53±3.81 mm ³ (P<0.05 compare to control). Benzo[a]pyrene administration significantly (P<0.05) decreases cAMP levels in tumors with adjacent lung tissues. The expression level of PDE4D gene is also increased by Benzo[a]pyrene administration.
类别有毒物品
毒性分级高毒
急性毒性皮下-大鼠 LD50: 50 毫克/公斤; 腹腔-小鼠 LDL0: 500 毫克/公斤
刺激数据皮肤-小鼠 0.014 毫克轻度
可燃性危险特性可燃; 燃烧产生刺激烟雾
储运特性通风低温干燥; 与库房食品原料分开存放
灭火剂干粉,泡沫,沙土,二氧化碳, 雾状水
职业标准 TWA 0.2 毫克/立方米