945725-50-8
中文名称
TASP 0277308
英文名称
TASP 0277308
CAS
945725-50-8
分子式
C23H28Cl2N6O3S
分子量
539.48
MOL 文件
945725-50-8.mol
结构式
基本信息
中文别名
英文别名
TASP 0277308
3,4-dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
3,4-dichloro-N-[(1R)-1-{4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-4H-1,2,4-triazol-3-yl}ethyl]benzenesulfonamide
3,4-dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
3,4-dichloro-N-[(1R)-1-{4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-4H-1,2,4-triazol-3-yl}ethyl]benzenesulfonamide
物理化学性质
| 沸点 | 707.5±70.0 °C(Predicted) |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | -10 to -25°C |
| 溶解度 | Soluble to 5 mM in DMSO |
| 酸度系数(pKa) | 7.90±0.50(Predicted) |
| 形态 | powder |
| 颜色 | white to beige |
应用领域
用途一
TASP0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP0277308 inhibited S1P- as well as VEGF-induced cellular responses, including migration and proliferation of human umbilical vein endothelial cells. Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo.
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产品介绍：
中文名称：化合物 TASP 0277308
英文名称：TASP 0277308
CAS：945725-50-8
包装信息：1removed