929551-91-7
中文名称
化合物 T30245
英文名称
Benzeneacetic acid, 3-[[[3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl][3-(dimethylamino)propyl]amino]methyl]-, methyl ester
CAS
929551-91-7
分子式
C27H41N7O4
分子量
527.66
MOL 文件
929551-91-7.mol
结构式
基本信息
中文别名
化合物 T30245
英文别名
AZ12441970
AZ-12441970
AZ 12441970
Benzeneacetic acid, 3-[[[3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl][3-(dimethylamino)propyl]amino]methyl]-, methyl ester
AZ-12441970
AZ 12441970
Benzeneacetic acid, 3-[[[3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl][3-(dimethylamino)propyl]amino]methyl]-, methyl ester
应用领域
用途一
AZ12441970 is a potent toll-like receptor 7 agonist (TLR7 agonist). AZ12441970 showed efficacy in a mouse allergic airway model with minimal induction of systemic IFN-α, consistent with the low plasma levels of compound. AZ12441970 induced high levels of the notch ligands Dll1 and Dll4 mRNA, whereas immobilized DLL4 resulted in the suppression of IL-5 production.