866927-10-8
基本信息
2-(((1H-苯并[D][1,2,3]三唑-6-基)氨基)甲基)-4,6-二氯苯酚
IC-87201 (IC87201
IC87201 >=98% (HPLC)
2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | DMF:30.0(Max Conc. mg/mL);97.04(Max Conc. mM) DMSO:29.0(Max Conc. mg/mL);93.81(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.81(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);3.23(Max Conc. mM) |
| 形态 | 固体 |
| 颜色 | Pink to red |
| InChI | InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19) |
| InChIKey | QEHVTUCLCBXQIC-UHFFFAOYSA-N |
| SMILES | C1(O)=C(Cl)C=C(Cl)C=C1CNC1C=C2NN=NC2=CC=1 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319 |
| 防范说明 | P305+P351+P338 |
| WGK Germany | WGK 3 |
| 存储类别 | 11 - Combustible Solids |
| 危险性类别 | Eye Irrit. 2 Skin Irrit. 2 |
866927-10-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-100457 | IC87201 | 866927-10-8 | 5 mg | 216元 |
| 2026/09/15 | HY-100457 | 866927-10-8 IC87201 | 866927-10-8 | 10mM * 1mLin DMSO | 237元 |
| 2026/09/15 | HY-100457 | 866927-10-8 IC87201 | 866927-10-8 | 10mg | 325元 |
常见问题列表
IC87201 (500-1800 μM) does not inhibit any of the probe-PDZ interactions involving PDZ1, PDZ2, PDZ3 of PSD-95 or nNOS-PDZ, or bind the canonical PDZ ligand binding sites. IC87201 binds to the β-finger of nNOS-PDZ and allosterically inhibits the nNOS-PDZ/PSD-95-PDZ interactions. IC87201 shows high degree of fluorescence-based artefactual signal when using TAMRA-nNOS as probe. IC87201 (20 μM) suppresses NMDA-stimulated cGMP formation relative to vehicle, in cultured hippocampal neurons. IC87201 (10 and 100 nM) attenuats NMDA/glycine-induced decreases in neurite outgrowth. IC87201 dose-dependently reduces NMDA-induced cGMP production in primary hippocampal neurons (DIV 14-21) with an IC 50 of 2.7 μM. IC87201 increases the number of branches at 10-30 μM when compared to control-treated neurons.
IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM).