85079-48-7
基本信息
化合物 T10609
toxint-17
Gb 3 toxin
BREVETOXIN3
PUMILIOTOXIN
brevetoxint17
BREVETOXIN PBTX-3
DIHYDROBREVETOXIN B
BKMHDYJRAAJTAD-RXUQWMQDSA-N
42-Hydroxy-42-deoxobrevetoxin B
物理化学性质
| 密度 | 1.190±0.06 g/cm3(Predicted) |
| 储存条件 | -20C |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 酸度系数(pKa) | 13.78±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | White to off-white |
| InChIKey | BKMHDYJRAAJTAD-FGRVLNGBSA-N |
安全数据
| 危险性符号(GHS) |   GHS06,GHS09 |
| 警示词 | 危险 |
| 危险性描述 | H300-H410 |
| 防范说明 | P264-P270-P273-P301+P310-P391-P405 |
| 危险品运输编号 | 3172 |
| WGK Germany | WGK 2 |
| RTECS号 | XW5885000 |
| 危险等级 | 6.1(a) |
| 包装类别 | I |
| 存储类别 | 3 - Flammable liquids |
| 危险性类别 | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
常见问题列表
IC50: voltage-gated Na + channel
Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .
| Animal Model: | Pregnant CD-1 mice |
| Dosage: | 2.8 μg/kg |
| Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 |
| Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |