81872-10-8
基本信息
1-NAPHTHYLACETIC ACID
AKOS AU36-M588
ALPHA-NAA
ALPHA-NAPHTHALENACETIC ACID
ALPHA-NAPHTHALENEACETIC ACID
ALPHA-NAPHTHYLACETIC ACID
a-Naphthylacetic acid
FRUIT FAX(R)
NAA
NAA(R)
NAA(TM)
NAPHTHALENE-1-ACETIC ACID
NAPHTHALENEACETIC ACID
PLANOFIX
RARECHEM AL BO 0198
ROOTONE(R)
1-NAPHTHYLACETICACIDα-NAPHTHYLACETICACID
1-[(S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4α-(phenylthio)-L-proline
S-Benzoyl-4-phenylthiocaptopril
物理化学性质
| 熔点 | 129-131.5 °C(lit.) |
| 比旋光度 | D25 -36.5° (c = 1 in methanol) |
| 沸点 | 646.3±55.0 °C(Predicted) |
| 密度 | 1.34±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: 5 mg/mL (11.64 mM) |
| 酸度系数(pKa) | pK1:4.236 (25°C) |
| 形态 | crystalline |
| 形态 | crystalline |
| 颜色 | light yellow |
| 颜色 | 淡黄色 |
| CAS 数据库 | 81872-10-8(CAS DataBase Reference) |
安全数据
| 危险品标志 | Xn,Xi |
| 危险类别码 | R22-R37/38-R41 |
| 安全说明 | S23-S24/25 |
| WGK Germany | 3 |
| RTECS号 | QJ0875000 |
| 危险等级 | IRRITANT |
常见问题列表
佐芬普利为首个含有巯基的长效ACE抑制剂，由于其含有巯基，因此使之具有亲脂性和抗氧化特性，本品可水解为活性物佐芬普利拉。
佐芬普利常见不良反应为有头晕（3.9％）、疲劳（2.6％）、头痛（2.4％）、咳嗽（1.2％）、恶心或呕吐（1.2％）。
不常见的不良瓜为潮红（0.8％）、肌痉挛（0.8％）和虚弱（0.5％）。
IC50: 81 μM (ACE)
Kinetic analyses demonstrate that enalapril inhibits the uptake of GlySar in a competitive manner (K i approximately 6 mM). Fosinopril and Zofenopril have the greatest inhibitory potency (IC 50 values of 55 and 81μM, respectively) while the other ACE inhibitors exhibit low-affinity interactions with the renal peptide transporter.
Zofenopril, a sulphydrylic compound, at doses higher than 70 mg/kg i.p. produces significant protection (i.e. at 70 mg/kg, P=0.044, F=2.17, d.f.=18; at higher concentration P<0.05) against the tonic phase of the audiogenic seizure response. Pretreatment with Zofenopril (15 mg/kg, i.p.) is able to produce a consistent shift to the left of the dose-response curves and a significant reduction of ED 50 values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity.
知名试剂公司产品信息
佐芬普利价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-108321S | 佐芬普利 Zofenopril-d5 | 81872-10-8 | 1 mg | 2350元 |
| 2025/02/08 | HY-108321 | 1-萘乙酸 Zofenopril | 81872-10-8 | 5mg | 1600元 |