77145-61-0
基本信息
4-氨基-1-(6-氯-2-吡啶基)哌啶盐酸盐
sr57227a
CM-57277
SR57227HCl
SR 57227 HYDROCHLORIDE
SR 57227A HYDROCHLORIDE
4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE
1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE
1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
4-amino-1-(6-chloro-2-pyridyl)piperidinemonohydrochloride
物理化学性质
| 储存条件 | Store at RT |
| 溶解度 | H2O: 9 mg/mL, soluble |
| 溶解度 | 在水中的溶解度为9 mg/mL |
| 形态 | solid |
| 颜色 | white |
安全数据
| 危险性符号(GHS) |  GHS06 |
| 警示词 | 危险 |
| 危险性描述 | H301-H315-H319-H335 |
| 防范说明 | P301+P310+P330-P302+P352-P305+P351+P338 |
| 危险品标志 | T |
| 危险类别码 | 25-36/37/38 |
| 安全说明 | 26-45 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| RTECS号 | TM3465250 |
常见问题列表
SR 57227A binds to 5-HT3 receptors labelled with [3H]S-zacopride with an affinity (K i ) of 115 nM in rat cerebral cortex, 150 nM in NG 108-15 cell membranes and 103 nM in whole NG 108-15 cell.
SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED
50
value for this effect of 14.2 mg/kg.
In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED
50
=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.).