74578-01-1
中文名称
化合物 T28960
英文名称
NSC135784
CAS
74578-01-1
分子式
C22H23NO8
分子量
429.43
MOL 文件
74578-01-1.mol
结构式
应用领域
用途一
Thaspine, also known as NSC 135784, is a natural compound and a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.