74578-01-1

Thaspine, also known as NSC 135784, is a natural compound and a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.

Thaspine acetate，一种生物碱，是一种拓扑异构酶 I 和 II 抑制剂。Thaspine acetate 可诱导癌细胞凋亡 (Apoptosis)。Thaspine acetate 可诱导 Bak 和 Bax 活化、线粒体细胞色素 c 释放和线粒体膜通透性增加。Thaspine acetate 可从南美树木巴豆的皮层中分离出来。