6736-58-9
基本信息
3-氮杂腺苷
3-脱氮腺苷
3-DEAZA-腺苷
4-氨基-1-BETA-D-呋喃核糖基-1H-咪唑并[4,5-C]吡啶
NSC 167897
3-Deaza-rA
3-DEAZAADENOSINE
3-Deaza-D-adenosine
3-Deazaadenosine ,98%
1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine
4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine
4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl-
物理化学性质
| 熔点 | 228-229°C |
| 沸点 | 665.7±65.0 °C(Predicted) |
| 密度 | 1.90±0.1 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O: 10 mg/mL with heating to 60 °C |
| 酸度系数(pKa) | 13.24±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至灰白色 |
| InChI | 1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1 |
| InChIKey | DBZQFUNLCALWDY-PNHWDRBUSA-N |
| SMILES | Nc1nccc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O |
安全数据
| 危险性符号(GHS) |  GHS06 |
| 警示词 | 危险 |
| 危险性描述 | H302+H312-H315-H319-H331-H335 |
| 防范说明 | P261-P280-P305+P351+P338-P311 |
| 安全说明 | 24/25 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 海关编码 | 29419090 |
| 存储类别 | 11 - Combustible Solids |
3-脱氮腺苷价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-W013332 | 3-脱氮腺苷 3-Deazaadenosine | 6736-58-9 | 1 mg | 1713元 |
| 2026/09/15 | HY-W013332 | 3-脱氮腺苷 3-Deazaadenosine | 6736-58-9 | 5 mg | 3900元 |
| 2026/09/15 | HY-W013332 | 3-脱氮腺苷 3-Deazaadenosine | 6736-58-9 | 10 mM * 1 mL in DMSO | 4290元 |
常见问题列表
IC50: 0.15 (HIV-1, A012 isolate), 0.20 µM (HIV-1, A018 isolate)
Ki: 3.9 µM (S-adenosylhomocysteine hydrolase)
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.