64048-12-0
中文名称
4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文名称
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
CAS
64048-12-0
分子式
C24H16N4S
分子量
392.48
更新日期
2024/09/02 10:25:03
结构式
中文别名
2,3,4,5-四-(4-吡啶)噻吩
2,3,4,5-四(4-吡啶基)噻吩
4,4?4乔,4乔?(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文别名
¥
GANT58
,4¥
4,4¥
Nsc75503
Hh/Gli Antagonist, GANT58
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
1,2,3,4-Tetrakis(4-pyridyl)thiophene
GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene
-(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
所属类别
生物化工:激动剂抑制剂
熔点 |
252-253℃ |
沸点 |
414.1±40.0 °C(Predicted) |
密度 |
1.254 |
储存条件 |
Keep in dark place,Sealed in dry,2-8°C |
溶解度 |
二甲基亚砜:>10mg/mL |
酸度系数(pKa) |
4.50±0.10(Predicted) |
形态 |
黄色固体 |
颜色 |
白色至淡黄色 |
4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine(64048-12-0)质谱(MS)4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine(64048-12-0)核磁图(1HNMR)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-13282 | 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine GANT 58 | 64048-12-0 | 5mg | 512元 |
2024/08/19 | HY-13282 | 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine GANT 58 | 64048-12-0 | 10mM * 1mLin DMSO | 563元 |
2024/08/19 | HY-13282 | 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine GANT 58 | 64048-12-0 | 10mg | 818元 |
生物活性
GANT 58 是一种有效的 Gli 拮抗剂,抑制 GLI1 诱导的转录,IC50 为 5 μM。
体外研究
GANT58 is a downstream inhibitor of Hh signaling. GANT58 is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked. GANT58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway. GANT58 (NSC75503) has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species). GANT58 has been shown to inhibit GLI transactivation.
体内研究
Nude mice are injected s.c. with GLI1-positive 22Rv1 prostate cancer cells, and tumors are established (median size ≈250 mm
3
). Nude mice are treated with daily s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). However, after 3 days, cyclopamine-treated animals presented with severe ulcerations at the injection sites. Therefore, changing the treatment regimen to injections only every second day. To be able to compare all compounds, this protocol is also introduced for the GANTs, although mice treated with these compounds showed no such signs of toxicity. All injections are done 2-3 cm away from the tumors. During an 18-day treatment period, suppression of tumor cell growth is observed for all compounds. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size.
供应商信息
更多
郑州如科生物科技有限公司
现货
联系电话:
15981811963
产品介绍:
中文名称:2,3,4,5-四-(4-吡啶)噻吩
英文名称:2,3,4,5-Tetra(4-pyridyl)thiophene
CAS:64048-12-0
纯度:98%
包装信息:5g;25g;100g;1kg
备注:优质现货;核心产品
库存量:
5g
现货日期:
2024/9/2 10:25:03
武汉易泰科技有限公司上海分公司
联系电话:
821-50328103-801 18930552037
产品介绍:
中文名称:4,4?4乔,4乔?(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文名称:GANT 58;2,3,4,5-Tetra(4-pyridyl)thiophene
CAS:64048-12-0
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海佰世凯化学科技有限公司
联系电话:
+86-21-20908456
产品介绍:
英文名称:2,3,4,5-Tetra(4-pyridyl)thiophene
CAS:64048-12-0
备注:C14401
上海健超生物科技有限公司
联系电话:
18017383231 18017383231
产品介绍:
中文名称:4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文名称:2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
CAS:64048-12-0
纯度:98%
包装信息:g;kg
备注:优势现货,常备库存
TargetMol中国(陶术生物)
联系电话:
021-021-33632979 15002134094
产品介绍:
中文名称:4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
CAS:64048-12-0
包装信息:1 mL;10 mg;100 mg;2 mg;25 mg;5 mg;50 mg
备注:试剂级,仅用于科研使用 90+%,具体纯度信息请见官网
上海毕得医药科技股份有限公司
联系电话:
400-164-7117 13681763483
产品介绍:
中文名称:2,3,4,5-四-(4-吡啶)噻吩
英文名称:4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine
CAS:64048-12-0
纯度:98%
包装信息:50mg;100mg;250mg;1g;5g;
南京百鑫德诺生物科技有限公司
联系电话:
025-58849295 18951903616
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
纯度:0.98
包装信息:1mg;5mg;10mg;25mg;50mg;100mg
备注:试剂
上海德欣致远生物技术有限公司
联系电话:
021-58088081 Q3252066219
产品介绍:
中文名称:2,3,4,5-四(4-吡啶基)噻吩
英文名称:2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
CAS:64048-12-0
纯度:98%
包装信息:1g;10g;100g
北京索莱宝科技有限公司
联系电话:
010-50973130 4009686088
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
江苏艾康生物医药研发有限公司
联系电话:
025-66113011 18112977050
产品介绍:
英文名称:4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine
CAS:64048-12-0
纯度:95% HPLC or GC
包装信息:10G,5G;1G
医恩医疗系统研发(上海)有限公司
联系电话:
021-58958002 18930822973
产品介绍:
英文名称:2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
CAS:64048-12-0
纯度:98% LC-MS
包装信息:10g, 50g, 100g, 1Kg
爱必信(上海)生物科技有限公司
联系电话:
021-38015121 15000105423
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
纯度:>98%
包装信息:10mg;5mg
上海传芊化工科技中心
联系电话:
15869524721
产品介绍:
CAS:64048-12-0
纯度:98% HPLC
包装信息:5MG;10MG;50MG;100MG,1G,5G,10G
郑州汇聚化工有限公司
联系电话:
0371-53736046 13393710386
产品介绍:
中文名称:2,3,4,5-四-(4-吡啶)噻吩
CAS:64048-12-0
纯度:98%
包装信息:1g;5g;25g
备注:本公司所有产品仅供科研生产用,不用于其它用途!可详询QQ:2853979814 微信:13393710386
MedBio脉铂医药
联系电话:
021-69568360 18916172912
产品介绍:
中文名称:4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文名称:2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
CAS:64048-12-0
纯度:98%
包装信息:50mg; 10mM (in 1mL DMSO); 10mg; 100mg; 5mg
备注:Medbio
成都超九八生物科技有限公司
联系电话:
13348960310 13348960310
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话:
010-60605840 15801484223
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
纯度:98%
包装信息:50mg;100mg;250mg;1g
上海优宁维生物科技股份有限公司
联系电话:
18768175414
产品介绍:
英文名称:GANT 58
CAS:64048-12-0
包装信息:10mg
备注: 见优宁维官网