基本信息 物理化学性质 7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-D][1,3]恶嗪盐酸盐价格(试剂级) 常见问题列表 供应商 相关产品
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600734-06-3

中文名称 7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-D][1,3]恶嗪盐酸盐
英文名称 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
CAS 600734-06-3
分子式 C22H25N3O4.ClH
分子量 431.917
MOL 文件 600734-06-3.mol
结构式 600734-06-3 结构式

基本信息

中文别名 7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-D][1,3]恶嗪盐酸盐
英文别名 Bay 65-1942 HCl
KINK-1 hydrochloride
Bay 65-1942 (HCl salt)
Bay 65-1942 (hydrochloride)
KINK-1 hydrochloride >=98% (HPLC)
(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride
7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)
所属类别 生物化工:激动剂抑制剂

物理化学性质

储存条件 -20°C
溶解度 DMSO : 50 mg/mL (115.76 mM; Need ultrasonic)
形态 粉末
颜色 白色至米色
旋光性 (optical activity) [α]/D -19 to -24°, c = 0.2 in DMF

常见问题列表

生物活性
Bay 65-1942 hydrochloride 是一种 ATP 竞争性的选择性 IKKβ 抑制剂。
靶点

IKKβ

体外研究

Delivery of Bay 65-1942 prior to ischemia significantly decreases left ventricular infarct size compared with animals receiving vehicle. Compared with sham animals, animals receiving vehicle have a significant increase in the infarct-to-area at risk (AAR) ratio (70.7±3.4 vs. 5.8±3.4%, P<0.05). This ratio is significantly reduced by treatment with Bay 65-1942 at each time point (prior to ischemia 42.7±4.1%, at reperfusion 42.7±7.5%, 2 h of reperfusion 29.4±5.2%; each group P<0.05 vs. vehicle). Animals pretreated with Bay 65-1942 (n=3) have significantly attenuated CK-MB levels compared with those animals without treatment prior to IR (14,170 ±3,219 units, P<0.05 vs. vehicle).

体内研究

Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC 50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 µM), BAY 65-1942 (10 µM), or a combination of these inhibitors at the same concentrations. AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 µM AZD6244+10 µM BAY 65-1942), which correlates with IC 75 (CI = 0.48±0.01). Synergism is also indicated at the IC 50 (CI = 0.56±0.09) and IC 90 (CI = 0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity.

供应商信息 更多

Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话: 021-61415566 800-8193336
产品介绍:
英文名称:KINK-1 hydrochloride
CAS:600734-06-3
纯度:>=98% (HPLC)
包装信息:25MG
备注:SML2098-25MG
北京索莱宝科技有限公司
联系电话: 010-50973130 4009686088
产品介绍:
英文名称:Bay 65-1942 Hydrochloride
CAS:600734-06-3
上海源溪生物科技有限公司
联系电话: 021-58447131 13564518121
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98% HPLC
包装信息:100mg,250mg,1g
广州优南科技有限公司
联系电话: 020-82000279 18988968278
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:5mg;10mg;50mg;100mg
爱必信(上海)生物科技有限公司
联系电话: 021-38015121 15000105423
产品介绍:
英文名称:Bay 65-1942 HCl
CAS:600734-06-3
纯度:>98%
包装信息:5mg;10mg
MedBio脉铂医药
联系电话: 021-69568360 18916172912
产品介绍:
中文名称:7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-D][1,3]恶嗪盐酸盐
英文名称:7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:10mg; 2mg; 5mg
备注:Medbio
成都超九八生物科技有限公司
联系电话: 13348960310 13348960310
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话: 010-60605840 15801484223
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:2mg;5mg;10mg
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
InvivoChem中国
联系电话: 13549236410
产品介绍:
英文名称:Bay 65-1942 HCl
CAS:600734-06-3
纯度:98% HPLC
包装信息:1mg
备注:V4192
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 Bay 65-1942 hydrochloride
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
包装信息:2mg/RMB 789;5mg/RMB 1410;25mg/RMB 5920
南京世洲生物科技有限公司
联系电话: 025-85560043 15850508050
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:98%
包装信息:10mg 100mg
銳迪國際科技有限公司
联系电话: 18024082417
产品介绍:
英文名称:Bay 65-1942 hydrochloride
CAS:600734-06-3
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g

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