591778-83-5

CP-610431 is an isozyme-nonselective ACC inhibitor. CP-610431 inhibited ACC1 and ACC2 with IC50s of approximately 50 nm. Inhibition was reversible, uncompetitive with respect to ATP, and non-competitive with respect to bicarbonate, acetyl-CoA, and citrate, indicating interaction with the enzymatic carboxyl transfer reaction.

CP-610431 是一种可逆的、ATP 非竞争性的、同工酶非选择性的乙酰辅酶 A 羧化酶 (ACC) 抑制剂。CP-610431 抑制 ACC1 和 ACC2，IC50 约为 50 nM。 CP-610431 可用于代谢综合征的研究。