58-82-2
基本信息
BK 舒缓激肽
缓激肽, >98%
化合物BRADYKININ
BRADYKININ游离态
亮氨酸脑啡肽 乙酸盐 水合物
舒缓激肽H-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH
[DES-PRO2]-BRADYKININ
ANGIOTENSIN I CONVERTING ENZYME (ACE I) INHIBITOR
brs640
prs640
C00306
RPPGFSPFR
BRADYZIDE
Callideic
KallidinⅠ
BRADYKININ
Callidin I
物理化学性质
| 熔点 | 170°C (rough estimate) |
| 比旋光度 | D25 -76.5° (c = 1.37 in 1N acetic acid) |
| 沸点 | 811.85°C (rough estimate) |
| 密度 | 1.1171 (rough estimate) |
| RTECS号 | EE1530000 |
| 折射率 | 1.6930 (estimate) |
| 储存条件 | −20°C |
| 储存条件 | −20°C |
| 溶解度 | H2O: >40 mg/mL |
| 溶解度 | H2O: >40 mg/mL |
| 酸度系数(pKa) | 3.34±0.10(Predicted) |
| 形态 | 白色至灰白色冻干固体 |
| 颜色 | 冻干粉 |
| 水溶解性 | Soluble to 1 mg/ml in water. |
| 序列 | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH |
| CAS 数据库 | 58-82-2 |
常见问题列表
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Human Endogenous Metabolite
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Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. Bradykinin has been reported to be involved in the progression of many types of cancer. Bradykinin treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin treatment stimulates ERK1/2 activation and IL-6 production. Exogenous bradykinin markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin on tissue factor expression.
Application of 1 μM bradykinin to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact. Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increases gradually after 48 h. PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA;B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava.