56985-40-1
基本信息
9,11-二脱氧基-11Α,9Α-亚甲基环氧前列腺素 F2Α
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液
9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α
9,11-Methanoxy-PGH2
9,11-Methanoepoxy PGH2
11α,9α-Epoxymethanoprostaglandin H2
U-46619 - CAS 56985-40-1 - Calbiochem
9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO
4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph
9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α
9,11-dideoxy-11A,9A-epoxymethano-*prostaglandin F
9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXY PGF2ALPHA
物理化学性质
| 沸点 | 519.7±30.0 °C(Predicted) |
| 密度 | 1.092±0.06 g/cm3(Predicted) |
| 闪点 | -10 °C |
| 储存条件 | -20°C |
| 溶解度 | ≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2 |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
| 形态 | solution |
| 颜色 | Colorless to light yellow |
| BRN | 4267334 |
安全数据
| 危险性符号(GHS) |   GHS02,GHS07 |
| 警示词 | 危险 |
| 危险性描述 | H225-H319-H336 |
| 防范说明 | P210-P305+P351+P338 |
| 危险品标志 | F,Xi |
| 危险类别码 | 11-36-66-67 |
| 安全说明 | 16-26 |
| 危险品运输编号 | UN 1231 3/PG 2 |
| 危险品运输编号 | UN 1231 3/PG 2 |
| WGK Germany | 2 |
| WGK Germany | 2 |
| RTECS号 | MJ9681090 |
| F | 8-10-23 |
| 毒性 | LD50 intravenous in mouse: 66ug/kg |
常见问题列表
U-46619是一种PGH2类似物，可以用作血栓烷A2（TP）受体激动剂，影响人类血管平滑肌的促有丝分裂生长。U 46619是稳定的血栓烷A2模拟物，是H2内过氧化物前列腺素的类似物，用作血管收缩剂和血栓烷受体激动剂。
TXA2
U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC
50
s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.
U-46619 (10 nM-10 μM) increases internal Ca
2+
concentration ([Ca
2+
]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.
U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).
| Animal Model: | 12-15 weeks-old male and female SHR |
| Dosage: | 5 μg/kg |
| Administration: | Intravenous injection |
| Result: | Induceed a significant increase of MABP after 1 min in male SHR. |
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-108566 | 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 U-46619 | 56985-40-1 | 1mg(28.5mM * 100μL in Methyl acetate) | 3300元 |
| 2024/08/19 | HY-108566 | 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 U-46619 | 56985-40-1 | 5mg(28.5mM * 500μL in Methyl acetate) | 9900元 |