53109-32-3
基本信息
(3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮
HIS-PRO, CYCLIC
Cyclo-Pro-His-HO
CYCLO(HIS-PRO), >99%
Cyclo(histidyl-proline)
Protirelin EP Impurity E
Cyclo(L-histidyl-L-proline)
histidylproline dioxopiperazine
Histidylproline diketopiperazine
CYCLO(HISTIDYL-PROLINE)
HISTIDYLPROLINE DIKETOPIPERAZINE
物理化学性质
| 熔点 | 162-164 °C |
| 沸点 | 659.3±48.0 °C(Predicted) |
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml |
| 酸度系数(pKa) | 12.73±0.40(Predicted) |
| 形态 | A neat oil |
| 颜色 | Light yellow to yellow |
| 化妆品成分功效 | HUMECTANT ANTIOXIDANT SKIN CONDITIONING - MISCELLANEOUS PRESERVATIVE SKIN PROTECTING |
| InChI | InChI=1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1 |
| InChIKey | NAKUGCPAQTUSBE-IUCAKERBSA-N |
| SMILES | [C@@]12([H])CCCN1C(=O)[C@H](CC1=CNC=N1)NC2=O |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338 |
| WGK Germany | 3 |
| 存储类别 | 11 - Combustible Solids |
环(组氨酰-脯氨酰)价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-101402 | 环(组氨酰-脯氨酰) Cyclo(his-pro) | 53109-32-3 | 1mg | 500元 |
| 2026/09/15 | HY-101402 | 环(组氨酰-脯氨酰) Cyclo(his-pro) | 53109-32-3 | 5mg | 900元 |
| 2026/09/15 | HY-101402 | 环(组氨酰-脯氨酰) Cyclo(his-pro) | 53109-32-3 | 10mg | 1500元 |
常见问题列表
|
NF-κB
|
Human Endogenous Metabolite
|
cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
| Cell Line: | PC12 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 2, 4, 8, 24, 48 hours |
| Result: | Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
| Animal Model: | Sixty two/three month-old male C57BL/6 mice (25-30 g) |
| Dosage: | 1.8 mg/ear |
| Administration: | Topical application on the right ear; 30 min prior to TPA |
| Result: | Reduced TPA-induced ear oedema. |