522-60-1
基本信息
乙基氢化脱甲奎宁
乙基氢化铜色树碱
乙基氢化铜色金鸡纳碱
numoquin
optoquine
Optochine
Numoquine
Ethylhydrocuprein
ETHYLHYDROCUPREINE
hydrocupreineethylether
Hydrocupureine ethyl ether
6’-ethoxy-hydrocinchonidin
物理化学性质
| 熔点 | 123-128° when solvent-free |
| 比旋光度 | D25 -136.2° (alcohol) |
| 沸点 | 476.25°C (rough estimate) |
| 密度 | 1.1027 (rough estimate) |
| 折射率 | 1.6180 (estimate) |
| 储存条件 | 2-8°C |
| 形态 | neat |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P264-P270-P301+P312-P501 |
| 危险品标志 | Xn |
| 危险类别码 | 22 |
| WGK Germany | 3 |
| RTECS号 | MW5950000 |
常见问题列表
S. pneumoniae
IC50: 25.75 nM (
Plasmodium falciparum
)
ggTas2r1,
ggTas2r2 and ggTas2r7
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.