5189-11-7
基本信息
苯噻啶苹果酸盐
苯噻啶苹果酸酯
双氯芬酸苹果酸盐
PIZOTIFEN苹果酸
苯噻啶苹果酸盐(偏头痛)
9,10-二氢-4-(1-甲基哌啶-4-亚基)-4H-苯并[4,5]环庚烷并[1,2-b]噻吩苹果酸盐 (1:1)
sanomtgran
bc105malate
litecmalate
malate(1:1)
Pizotifen Mala
Einecs 225-970-4
PIZOTIFEN MALATE
sandomygranmalate
PIZOTYLINE MALATE
物理化学性质
| 熔点 | 185-186° (dec) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 酸水溶液（微溶，加热）、DMSO（微溶）、甲醇（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至灰白色 |
| 稳定性 | 吸湿性 |
| 主要应用 | pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9) |
| InChIKey | IWAWCPZVTXCFKD-UHFFFAOYSA-N |
| SMILES | [s]1c2c(cc1)C(=C4CCN(CC4)C)c3c(cccc3)CC2.OC(CC(=O)O)C(=O)O |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-37/39 |
| WGK Germany | WGK 3 |
| 存储类别 | 11 - Combustible Solids |
应用领域
苯噻啶苹果酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-B0115A | 苯噻啶苹果酸盐 Pizotifen malate | 5189-11-7 | 100 mg | 200元 |
| 2026/09/15 | HY-B0115A | 苯噻啶苹果酸盐 Pizotifen malate | 5189-11-7 | 10 mM * 1 mL in DMSO | 220元 |
| 2026/07/06 | S1394 | 苯噻啶苹果酸盐 Pizotifen Malate | 5189-11-7 | 50mg | 804.86元 |
常见问题列表
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5-HT 2A Receptor
|
5-HT 1C Receptor
|
Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.