51598-60-8
基本信息
溴化N-(环丙基甲基)东莨菪碱
Cimetropium
DA-3177：Alginor
Cimetropiumbromid
Cimetronin bromide
CIMETROPIUM BROMIDE
N-Cyclopropvlmethylscopolamine bromide
(7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide
物理化学性质
| 外观性状 | 从乙腈结晶，熔点174℃。[α] D20-18.3°(C=3)。 |
| 熔点 | 174° |
| 比旋光度 | D20 -18.3° (c = 3) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | DMSO（少许）、甲醇（少许）、水（少许） |
| 形态 | 固体 |
| 颜色 | 白色 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P264-P270-P301+P312-P330-P501 |
应用领域
制备方法
西托溴铵价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 1 mg | 350元 |
| 2024/11/08 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 5mg | 650元 |
| 2024/11/08 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 10mM * 1mLin Water | 715元 |
常见问题列表
mAChR
Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition.
When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID 50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension.