514-67-0
基本信息
514-67-0
Rubropuncatatin
(9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione
(R-(E))-9A-Methyl-3-(1-oxohexyl)-6-(1-propenyl)-2H-furo(3,2-G)(2)benzopyran-2,9(9ah)-dione
(R)-9a-Methyl-3-(1-oxohexyl)-6-[(E)-1-propenyl]-2H-furo[3,2-g][2]benzopyran-2,9(9aH)-dione
2H-Furo(3,2-G)(2)benzopyran-2,9(9ah)-dione, 9A-methyl-3-(1-oxohexyl)-6-(1-propenyl)-, (R-(E))-
2H-Furo[3,2-g][2]benzopyran-2,9(9aH)-dione, 9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propen-1-yl-, (9aR)-
物理化学性质
| 熔点 | 156.5-157.0 °C (decomp)(Solv: ethyl ether (60-29-7)) |
| 沸点 | 638.8±55.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 形态 | Solid |
| 颜色 | Yellow to orange |
常见问题列表
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.
Cell Viability Assay
| Cell Line: | BGC-823 and GES-1cells |
| Concentration: | 1.5, 3, 6, 12, 15, 18, 30 μM |
| Incubation Time: | 24 hours |
| Result: |
Decreased the viability of BGC-823 cells with an IC
50
of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells. |
Cell Cycle Analysis
| Cell Line: | BGC-823 cells |
| Concentration: | 0, 5, 10, 30 μM |
| Incubation Time: | 0, 6, 12, 24 hours |
| Result: |
Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
|
Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.
Rubropunctamine inhibits 12-
O
-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID
50
of 0.11 mg/ear.
| Animal Model: | Male nude mice (5 weeks) are inoculated with BGC-823 cells |
| Dosage: | 8, 32 mg/kg |
| Administration: | I.v. five times (day 1st, 4th, 7th, 10th, and 13th) |
| Result: |
Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight. |