497061-48-0
基本信息
DC_AC50 (DC-AC50
DC_AC50 >=98% (HPLC)
3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
5H-Cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-
物理化学性质
| 沸点 | 485.1±45.0 °C(Predicted) |
| 密度 | 1.759±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.80±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至浅棕色 |
| InChI | 1S/C17H12BrF2N3OS/c18-10-5-8(19)6-11(20)14(10)23-16(24)15-13(21)9-4-7-2-1-3-12(7)22-17(9)25-15/h4-6H,1-3,21H2,(H,23,24) |
| InChIKey | DFNOJNBNTVQPCA-UHFFFAOYSA-N |
| SMILES | NC1=C(C(NC2=C(Br)C=C(F)C=C2F)=O)SC3=NC4=C(CCC4)C=C31 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P305+P351+P338 |
| WGK Germany | WGK 3 |
| 存储类别 | 11 - Combustible Solids |
| 危险性类别 | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
DC_AC50价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-107636 | DC_AC50 | 497061-48-0 | 1 mg | 386元 |
| 2026/09/15 | HY-107636 | DC_AC50 DC_AC50 | 497061-48-0 | 5mg | 850元 |
| 2026/09/15 | HY-107636 | DC_AC50 | 497061-48-0 | 10 mM * 1 mLin DMSO | 935元 |
常见问题列表
DC_AC50 exhibits IC
50
values of 9.88 μM, 12.57 μM, 5.96 μM and 6.68 μM in Canine Abrams, Canine D1, human HOS and human MG63) cells, respectively.
DC_AC50 (0-10 μM)-treated cells are significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.
DC_AC50 (10 μM) potentiates carboplatin-induced apoptosis in OSA cells and decreasesclonogenic survival.
DC_AC50 induces cell cycle arrest at both the 3 and 10 μM doses and DC_AC50 induces increase S phase cells dose-independently.
DC_AC50 (3 μM) inhibits the migration and of canine and human OSA cells.
DC_AC50 (2.5-10 μM) is highly efficient at inhibiting cancer cell proliferation (human lung cancer H1299 cells, leukaemia cancer K562 cells, breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells) in a dose-dependent manner. DC_AC50 fails to exhibit any notable inhibition of the cell proliferation of human normal epithelial lung BEAS-2B cells or breast MCF-10A cells as control cells.
Cell Viability Assay
| Cell Line: | Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells. |
| Concentration: | 0-10 μM. |
| Incubation Time: | 72 h. |
| Result: | Dose-dependently decreased viability of OSA cells. |
Apoptosis Analysis
| Cell Line: | Abrams and HOS cells. |
| Concentration: | 1, 3 and 10 μM (10 μM Carboplatin). |
| Incubation Time: | 24 h. |
| Result: | Potentiated carboplatin-induced apoptosis. |