4696-76-8
基本信息
卡那霉素杂质B
妥布霉素EP杂质A
卡那霉素 B?, >98%
NK-1006
NK 1006
KANAMYCIN B
Bekanamycin
nebramycinv
kanendomycin
Kanamycin B base
nebramycinfactor5
Bekanamycin, >98%
物理化学性质
| 熔点 | 178-182° (dec) |
| 比旋光度 | D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
| 沸点 | 580.49°C (rough estimate) |
| 密度 | 1.3771 (rough estimate) |
| 折射率 | 1.7600 (estimate) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 酸水溶液（微溶）、甲醇（微溶、加热、超声处理） |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | Crystals |
| 稳定性 | 吸湿性 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315; H319; H335 |
| 防范说明 | P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501 |
| 毒性 | LD50 i.v. in mice: 136 mg/kg (Wakazawa) |
应用领域
卡那霉素 B价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-B1174 | 卡那霉素 B Bekanamycin | 4696-76-8 | 100mg | 267元 |
| 2024/11/08 | HY-B1174 | 卡那霉素 B Bekanamycin | 4696-76-8 | 10mM * 1mLin Water | 293元 |
常见问题列表
Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of
S. kanamyceticus
.
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals.