基本信息 物理化学性质 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE价格(试剂级) 常见问题列表 供应商 相关产品
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459836-30-7

中文名称 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
CAS 459836-30-7
分子式 C34H32Br2N6Na4O11P2
分子量 1014.37
MOL 文件 459836-30-7.mol
结构式 459836-30-7 结构式

基本信息

英文别名 PEAQX TETRASODIUM HYDRATE
NVP-AAM077 tetrasodiuM hydrate
NVP-AAM 077 tetrasodiuM hydrate
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

物理化学性质

储存条件 -20°C

常见问题列表

生物活性
PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂,其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。
体外研究

PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.

体内研究

PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F 3, 73 =4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.

Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage: 10, 20 or 40 mg/kg.
Administration: S.C.
Result: Showed a sensitized locomotor response to PCP challenge on PN28-35.
Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage: 4 mg/kg.
Administration: I.P.
Result: Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
Animal Model: 11-week old C57BL/6 mice.
Dosage: 10 mg/kg.
Administration: IP.
Result: Reversed the effect of PRE084 (F 3,78 = 10.446, p<0.01).

供应商信息 更多

Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话: 021-61415566 800-8193336
产品介绍:
英文名称:PEAQX tetrasodium hydrate
CAS:459836-30-7
纯度:>=98% (HPLC)
包装信息:25MG
备注:P1999-25MG
天津普西唐生物医药科技有限公司
联系电话: 010-60605840 15801484223
产品介绍:
英文名称:PEAQX tetrasodium hydrate
纯度:98%
包装信息:5mg;10mg;50mg
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 PEAQX tetrasodium hydrate
英文名称:PEAQX tetrasodium hydrate
纯度:98%
包装信息:200 mg