基本信息 物理化学性质 常见问题列表 供应商 相关产品
网站主页Cas数据库列表41020-79-5

41020-79-5

中文名称 地西利酮
英文名称 Dicirenone
CAS 41020-79-5
分子式 C26H36O5
分子量 428.56
MOL 文件 41020-79-5.mol
结构式 41020-79-5 结构式

基本信息

中文别名 地西利酮
英文别名 SC 26304
Dicirenone
(17R)-17-Hydroxy-3-oxo-7α-(isopropyloxycarbonyl)pregn-4-ene-21-carboxylic acid γ-lactone
Pregn-4-ene-7,21-dicarboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, 1-methylethyl ester, (7α,17α)-

物理化学性质

沸点 579.3±50.0 °C(Predicted)
密度 1.18±0.1 g/cm3(Predicted)

常见问题列表

生物活性
Dicirenone (SC26304) 抑制醛固酮对尿 K+:Na+ 比例的调节作用,也抑制 [3H] 醛固酮与肾细胞质和核受体结合作用。
体内研究

Cytoplasmic binding of [ 3 H]Aldosterone and [ 3 H]Dicirenone is similar in magnitude and involves the same set of sites. Under three sets of conditions-(i) in the intact rat, (ii) in kidney slices, and (iii) in reconstitution studies (mixing prelabeled cytoplasm with either purified renal nuclei or chromatin), [ 3 H]Dicirenone does not yield specific nuclear complexes in contrast to the reproducible generation of these complexes with [ 3 H]Aldosterone. In glycerol density gradients, cytoplasmic [ 3 H]Aldosterone receptor complexes sediment at 8.5 S and 4 S in low concentrations of salt and at 4.5 S in high concentrations of salt. Cytoplasmic [ 3 H]Dicirenone receptor complexes sediment at 3 S in low concentrations of salt and 4 S in high concentrations of salt. These results are discussed in terms of an allosteric model of the receptor system. Administration of Dicirenone (SC-26304) alone in doses of 3-600 μg/100 g of body weight has no effect on urinary Na + :creatinine or K + :creatinine ratios. These results are expressed as urinary K + :Na + ratios. Aldosterone (0.3 μg/100 g of body weight) increases the K + :Na + ratio 5-fold. This increase is significantly inhibited by 180 μg/100 g of body weight of Dicirenone and completely inhibit by 600 μg/100 g of body weight. To correlate inhibitory action and receptor occupancy, the same doses of Dicirenone are given to rats injected with 0.036 μg of [ 3 H]Aldosterone. A dose of 180 μg of body weight reduces specific binding of Aldosterone in cytoplasmic and nuclear fractions to less than half of the control levels and 600 μg/100 g of body weight eliminated specific binding. The dose of Aldosterone used in the physiological studies is about eight times that used in the binding studies, but both doses are well below saturating amounts.

供应商信息 更多

天津普西唐生物医药科技有限公司
联系电话: 010-60605840 15801484223
产品介绍:
英文名称:Dicirenone
CAS:41020-79-5
包装信息:1mg;5mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:地西利酮
英文名称:Dicirenone
CAS:41020-79-5
纯度:99.1%
包装信息:5mg/RMB 12600;1mg/RMB 4900
銳迪國際科技有限公司
联系电话: 18024082417
产品介绍:
英文名称:Dicirenone
CAS:41020-79-5
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g
sangon
联系电话:
产品介绍:
中文名称:地西利酮
英文名称:Dicirenone
CAS:41020-79-5

相关产品