402934-09-2

BBS4 is a potent, orally active and selective inducible nitric oxide synthase dimerization inhibitor. BBS4 inhibits the dimerization of iNOS monomers, thus preventing the formation of the dimeric, active form of the enzyme. BBS4 significantly ameliorated adjuvant-induced arthritis in a rat model. BBS4 blocks the formation of the protein-protein interaction present in the dimeric form of iNOS. BBS4 prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice.

BBS-4 是一种有效的、选择性诱导型一氧化氮合酶 (NOS2) 二聚抑制剂，IC50 值为 0.49 nM。BBS-4 可以保护小鼠免受败血症的心血管功能障碍的影响。