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38647-11-9

供应商 相关产品 基本信息 理化性质 应用领域 常见问题列表 雷公藤内酯酮价格(试剂级)

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基本信息

中文
雷公藤内酯酮
英文名称
PG 492
NSC 165677
TRIPTONIDE
Triptonide USP/EP/BP
14-Deoxy-14-oxotriptolide
Triptolide,14-deoxy-14-oxo
TRIPTONIDE(PRIMARY STANDARD)
Triptonide, 98%, from Peucedanum praeruptorum Dunn
(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-
CAS
38647-11-9
中文名称
雷藤酮
雷公藤羰内酯
雷公藤内酯酮
雷公藤内酯酮(雷藤酮
雷藤酮 ,雷公藤羰内酯
雷公藤内酯酮(标准品)
雷公藤内酯酮, 来源于前胡
雷公藤内酯酮TRIPTONIDE
雷公藤内酯酮(雷藤酮 ,雷公藤羰内酯)
分子式
C20H22O6
分子量
358.39
MOL 文件
38647-11-9.mol

理化性质

外观性状
黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于雷公藤。
熔点 
251~252℃
沸点 
581.1±50.0 °C(Predicted)
密度 
1.48±0.1 g/cm3(Predicted)
储存条件 
Inert atmosphere,Store in freezer, under -20°C
CAS 数据库
38647-11-9

应用领域

用途1
雷公藤内酯酮具有抗肿瘤 免疫调节 抗炎的作用。

常见问题列表

概述
雷公藤内酯酮是从雷公藤中分离得到的一个二萜类化合物,是雷公藤的有效成份之一,它与雷公藤内酯醇结构相似,活性也相当,其结构式如下。雷公藤内酯酮具有抗雄性生育作用和对免疫功能具有一定的影响。
生物活性
Triptonide (NSC 165677;PG 492) 是从雷公藤中鉴定出的一种天然产物。Triptonide 是一种 Wnt 信号抑制剂,其 IC50 约为 0.3 nM。Triptonide 具有免疫抑制、抗炎、抗生育、神经保护和抗淋巴瘤作用。
靶点
TargetValue
Wnt/β-catenin
()

体外研究

Triptonide blocks Wnt/β-catenin signaling via C-terminal transactivation domain of β-catenin, and promots apoptosis in Wnt-dependent cancer cells.
Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC 50 of 5.7 nM and 4.8 nM, respectively.
Triptonide (2.5-10 nM; 6 days) significantly suppresses B-lymphoma cell colony-forming capability.
Triptonide (20 nM; 3 days) promotes apoptosis through activation of PARP and caspase 3, but reduction of BCL2 protein levels in the lymphoma cells.
Triptonide (5-10 nM; 72 hours) markedly reduces both total and phosphorylated Lyn proteins, and diminishes Lyn downstream ERK and ATK signal pathways.

Cell Proliferation Assay

Cell Line: B-lymphoma Raji cells, T-lymphoma Jurkat cells
Concentration: 0-80 nM
Incubation Time: 3 days, 6 days
Result: Inhibited lymphoma cell tumorigenic capability in a dose-dependent manner.

Apoptosis Analysis

Cell Line: Raji cells
Concentration: 5 nM, 10 nM, 20 nM
Incubation Time: 3 days
Result: Did not significantly induce apoptosis at the effective tumor growth-inhibitory (2.5-10 nM); moderately induced lymphoma cell apoptosis (20 nM).

Western Blot Analysis

Cell Line: Raji cells
Concentration: 5 nM, 10 nM, 20 nM
Incubation Time: 3 days
Result: Did not vigorously activated pro-apoptotic proteins PARP and caspase 3 in lymphoma cells (5-10 nM); significantly activated PARP and caspase 3 (20 nM); significantly reduced anti-apoptotic BCL2 levels.

RT-PCR

Cell Line: Raji cells
Concentration: 5 nM, 10 nM
Incubation Time: 72 hours
Result: Significantly diminished Lyn mRNA levels in the lymphoma cells.

体内研究

Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice.

Animal Model: Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 10 7 Raji cells xenograft
Dosage: 5 mg/kg
Administration: Intraperitoneal injection, daily, for 34 days
Result: Potently inhibited lymphoma cell growth and tumorigenic capability.

雷公藤内酯酮价格(试剂级)

雷公藤内酯酮价格(试剂级)
更新日期产品编号产品名称包装价格
2021/06/02S9416雷公藤内酯酮
Triptonide
1mg1204.68元
2021/03/30S9416雷公藤内酯酮
Triptonide
1mg1204.68元

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