321661-62-5
基本信息
NUR77激动剂(CYTOSPORONE B)
Cytosporone B
Dothiorelone G
ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE
物理化学性质
| 沸点 | 471.6±24.0 °C(Predicted) |
| 密度 | 1.126±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 酸度系数(pKa) | 7.54±0.40(Predicted) |
| 形态 | 结晶固体 |
| 颜色 | 白色至灰白色 |
| InChI | InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3 |
| InChIKey | UVVWQQKSNZLUQA-UHFFFAOYSA-N |
| SMILES | C1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302 |
| 防范说明 | P264-P270-P301+P312-P501 |
| 危险品标志 | Xn |
| 危险类别码 | 22 |
| WGK Germany | 3 |
CSN-B价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 2mg | 770元 |
| 2024/11/08 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 5mg | 1100元 |
| 2024/11/08 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 10mM * 1mLin DMSO | 1365元 |
常见问题列表
| Target | Value |
|
Nur77
(Cell-free assay) | 0.278 nM(EC50) |
Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC 50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells.
In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min.