3105-97-3
基本信息
羟甲硫蒽酮
1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮
hycanthon
nsc-134434
Win 249-33
HYCANTHONE
Etrenol(mesylate)
lucanthonemetabolite
1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one
1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one
1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on
物理化学性质
| 外观性状 | 淡黄色至黄橙色结晶粉末。 |
| 熔点 | 100.6-102.8° |
| 沸点 | 570.5±50.0 °C(Predicted) |
| 密度 | 1.1269 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | DMSO : 30 mg/mL (84.16 mM) |
| 酸度系数(pKa) | pKa 3.40 (Uncertain) |
| 形态 | Solid |
| 颜色 | Yellow to orange |
| EPA化学物质信息 | Hycanthone (3105-97-3) |
安全数据
| 危险性符号(GHS) |   GHS07,GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H302-H332-H350-H312 |
| 防范说明 | P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 |
| 危险品标志 | T |
| 危险类别码 | 45-46-20/21/22 |
| 安全说明 | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS号 | XO1590000 |
应用领域
常见问题列表
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Topoisomerase I
|
Topoisomerase II
|
Hycanthone has an IC
50
of 80 nM for inhibition of APE1 incision of depurinated plasmid DNA.
Hycanthone (0.05-100 µM; for 2 h) promotes APE1 cleavage in presence of Cycloheximide (CHX) and this cleavage is inhibited by 1% DMSO.
Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Results reveal that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively reduces viral interferon yields as much as 73% compare to that of controls.
Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules.