30286-75-0
基本信息
溴化氧托溴铵
化合物 T16417
氧托溴铵 EP标准品
ba253br
Oxivent
Ventilat
Tersigan
tersigat
oxitropium
ba-253-br-l
Oxitropiumbromid
oxitropiobromuro
物理化学性质
| 熔点 | 203-204° (dec) |
| 比旋光度 | D21 -25° (c = 2.0 in water) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| 形态 | neat |
| 颜色 | 灰白色至淡黄色 |
| 稳定性 | 吸湿性 |
安全数据
| 毒性 | LD50 orl-rat: 2250 mg/kg DRFUD44,117,79 |
常见问题列表
mAChR
Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro ; however, it causes both types of muscle to be fatigue resistant.
Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo . Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.