300817-68-9
基本信息
BHI1
BH 3I1
BH3I 1
BH3I1
5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid
5-(p-Bromobenzylidene)-a-isopropyl-4-oxo-2-thioxo-3-thiazolidine acetic acid
3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-
物理化学性质
| 沸点 | 535.2±60.0 °C(Predicted) |
| 密度 | 1?+-.0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | DMSO: >10 mg/mL, soluble |
| 酸度系数(pKa) | 3.39±0.10(Predicted) |
| 形态 | powder, yellow |
| 颜色 | Light yellow to yellow |
| InChI | 1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+ |
| InChIKey | COHIEJLWRGREHV-YRNVUSSQSA-N |
| SMILES | CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302+H312+H332 |
| 防范说明 | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
| 危险品标志 | Xn |
| 危险类别码 | 20/21/22 |
| 安全说明 | 36 |
| WGK Germany | 3 |
| 存储类别 | 11 - Combustible Solids |
| 危险性类别 | Acute Tox. 4 Oral |
BH3I-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-100383 | BH3I-1 BH3I-1 | 300817-68-9 | 5 mg | 650元 |
| 2026/09/15 | HY-100383 | BH3I-1 BH3I-1 | 300817-68-9 | 10 mM * 1 mL in DMSO | 715元 |
| 2026/09/15 | HY-100383 | BH3I-1 BH3I-1 | 300817-68-9 | 10 mg | 1050元 |
常见问题列表
|
Bcl-2
|
Bcl-xL
|
Bim
|
Bak
|
p53/mDM2 5.3 μM (Kd) |
BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1α interactions. This surprising promiscuity, displays by a well studied compound leads to further interrogate the p53/hDM2 interaction utilizing a standard fluorescence polarization (FP) assay with purified protein. The results from the FP assay validates the split-luciferase screen and demonstrates that BH3I-1 has a K d =5.3 μM against the p53/mDM2 pair, which is comparable to its low micromolar potency reported for the BH3 family of receptors. BH3I-1 inhibits interaction between the BH3 domain and Bcl-xL. NMR analyses reveal that BH3I-1 targets the BH3-binding pocket of Bcl-xL with a K i of 7.8±0.9 μM.