286008-51-3
中文名称
化合物 T28509
英文名称
1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-
CAS
286008-51-3
分子式
C18H16ClF3N6
分子量
408.81
MOL 文件
286008-51-3.mol
结构式
基本信息
中文别名
化合物 T28509
英文别名
RDR03871
RDR-03871
RDR 03871
1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-
RDR-03871
RDR 03871
1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-
应用领域
用途一
RDR03871 is an MDM2 inhibitor. Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2 frequently occur in human cancers, and are associated with poor prognosis, advanced forms of the disease, and chemoresistance. MDM2, the major negative regulator of p53, induces p53 degradation and inactivates its tumor suppressing activity.