2738-64-9
基本信息
粉蝶霉素A
杀粉蝶菌素A
IT-143D
piericidin
piericidinea
PIERICIDIN A
PIERICIDIN A1
SHAOGUAMYCIN B
SHAOGUANMYCIN B
piericidin(sub1)
piericidin a from microbial source
物理化学性质
| 沸点 | 614.9±55.0 °C(Predicted) |
| 密度 | 1.044±0.06 g/cm3(Predicted) |
| 闪点 | 85 °C |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（高达25mg/ml）或乙醇（高达20mg/ml）。 |
| 酸度系数(pKa) | 5.21±0.33(Predicted) |
| 形态 | liquid |
| 颜色 | green-yellow |
| 稳定性 | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month. |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P271-P280 |
| 危险品标志 | T+,Xn |
| 危险类别码 | 26/27/28-20/21/22 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 3382 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS号 | YD4588000 |
| F | 3-10 |
| 海关编码 | 2933399990 |
粉蝶霉素A价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-114936 | 粉蝶霉素A Piericidin A | 2738-64-9 | 1mg(12.03mM * 200μL in Ethanol) | 4500元 |
常见问题列表
In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC
50
value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC
50
value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.
Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S +/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S +/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S +/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.