24418-86-8
基本信息
2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮
Sphingosine Kinase Inhibitor V
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one
2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-
(2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one
(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V
物理化学性质
| 沸点 | 493.2±45.0 °C(Predicted) |
| 密度 | 1.489±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | DMSO: 250 mg/mL (983.32 mM) |
| 酸度系数(pKa) | 8.99±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319 |
| 防范说明 | P280-P264-P305+P351+P338-P337+P313 |
2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-12895 | 2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮 SKI V | 24418-86-8 | 5mg | 1500元 |
| 2024/08/19 | HY-12895 | 2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮 SKI V | 24418-86-8 | 10mM * 1mLin DMSO | 1650元 |
| 2024/08/19 | HY-12895 | 2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮 SKI V | 24418-86-8 | 10mg | 2500元 |
常见问题列表
IC50: 2 μM (GST-hSK), 6 μM (hPI3k) and 80 μM (ERK2)
SKI V has weak activity toward ERK2 (
IC
50
of 80 μM for hERK2) and does not inhibit PKC-α.
SKI V (10 μM; for 24 hours) inhibits cancer cell proliferation and induces apoptosis.
SKI V (0.2, 1, 5 μM; pretreated for 1 hour) decreases phospho-Akt and phospho-MEK levels. Near-confluent cultures of JC cells are serum-starved for 16 hours, followed by pretreatment SKI V for 1 hour.
SKI V has IC
50
s for inhibition of sphingosine kinase (SK) and tumor cell proliferation of ∼2 μM.
SKI V (20 μg/ml) inhibits not only purified but endogenous SK in in MDA-MB-231 cells.
SKI V (0.2, 1, 5 μM) inhibits intracellular S1P formation in JC cells in a dose-dependent fashion.
Cell Proliferation Assay
| Cell Line: | T24 tumor cells |
| Concentration: | 10 μM |
| Incubation Time: | For 24 hours |
| Result: | Inhibited cancer cell proliferation. |
Apoptosis Analysis
| Cell Line: | T24 tumor cells |
| Concentration: | 10 μM |
| Incubation Time: | For 24 hours |
| Result: | Induced apoptosis. |
Western Blot Analysis
| Cell Line: | JC cells |
| Concentration: | 0.2, 1, 5 μM |
| Incubation Time: | Pretreated for 1 hour |
| Result: | Decreased phospho-Akt and phospho-MEK levels. |
SKI V (75 mg/kg; i.p.; days 1, 5, 9, 15) significantly lowers tumor growth (>50% decreased at day 18) than control animals.
| Animal Model: | 6-8 weeks old BALB/c female mice with JC mammary adenocarcinoma cells |
| Dosage: | 75 mg/kg |
| Administration: | IP; days 1, 5, 9, 15 |
| Result: | Tumor growth was significantly lower (>50% decreased at day 18) than tumor growth in control animals. |