220355-63-5
基本信息
UKI-1C
1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester
物理化学性质
| 沸点 | 745.5±70.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO : ≥ 28 mg/mL (45.62 mM) |
| 酸度系数(pKa) | 9.76±0.50(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
220355-63-5价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-100415 | 220355-63-5 UKI-1 | 220355-63-5 | 1mg | 1500元 |
| 2024/08/19 | HY-100415 | 220355-63-5 UKI-1 | 220355-63-5 | 5mg | 3500元 |
| 2024/08/19 | HY-100415 | 220355-63-5 UKI-1 | 220355-63-5 | 10mM * 1mLin DMSO | 4726元 |
常见问题列表
Ki: 0.41 μM (Urokinase-type plasminogen activator (uPA))
Serine protease
UKI-1 (WX-UK1; 0.1-1.0 μg/mL) treatment shows a decrease of tumor cell invasion by up to 50% is achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa.
UKI-1 (WX-UK1) interferes with the plasminogen activation system at 2 levels: it inhibits plasmin formation directly and via inhibition of uPA. In vitro invasion models with highly invasive fibrosarcoma and breast cancer cells showed that UKI-1 effectively inhibits migration of the cells through fibrin matrices.
UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models.