213262-83-0

AN-7 is a potent HDAC inhibitor, is also a prodrug of butyric acid, which induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells in vitro and in vivo. AN-7 is likely to display a high therapeutic index and may be beneficial for prostate cancer patients.

AN-7 是一种具有口服活性的组蛋白去乙酰化酶 (HDAC) 抑制剂，在体外和体内诱导组蛋白过度乙酰化和分化，抑制人前列腺 22Rv1 癌细胞的增殖。AN-7 能够增加促凋亡蛋白 Bax 的表达，降低抗凋亡蛋白 Bcl-2 的表达，并通过激活 caspase-3 来促进细胞凋亡 (apoptosis)，可用于前列腺癌的研究。