204718-47-8
基本信息
2-Thiazolecarboxamide, 4-(4-fluorophenyl)-5-[2-[4-[(3-fluorophenyl)methylene]-1-piperidinyl]ethyl]-
物理化学性质
| 沸点 | 625.3±65.0 °C(Predicted) |
| 密度 | 1.297±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.89±0.50(Predicted) |
常见问题列表
|
D 4 Receptor 0.48 nM (Ki) |
D 3 Receptor 39 nM (Ki) |
5-HT 2A Receptor 180 nM (Ki, in rat) |
Rat α1 adrenoceptor 237 nM (Ki) |
NRA0160 (0.1, 1, or 3 mg/kg, i.p.) has no effect on PCP-induced hyperlocomotion, stereotypy or ataxia in SD rats. NRA0160, at any dose, does not reduce cumulated counts of locomotion and cumulated scores of stereotypy emerging, and has no effect on extracellular glutamate levels and locomotor activity emerged after saline injection. NRA0160 dose-dependently and significantly reverses the effects of MAP on both A9 and Al0 dopamine neurons. NRA0160 is slightly more potent in reversiig the effects of MAP on A10 (ED 50 = 1.0 mg/kg) than on A9 dopamine neurons (ED 50 = 1.3 mg/kg). NRA0160 reverses the effect of AP0 on both A9 and A10 dopamine neurons. ED 50 values for the effects of NRA0160 on APO-induced inhibition of A9 and A10 dopamine neurons are 1.3 mg/kg and 0.5 mg/kg, respectively.