204592-94-9
基本信息
LY-377604,LY377604
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
物理化学性质
| 沸点 | 809.4±65.0 °C(Predicted) |
| 密度 | 1.282±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.94±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | Off-white to light brown |
常见问题列表
EC50: 2.4 nM (human β 3 -adrenergic receptor) β 1 -adrenergic receptor, β 2 -adrenergic receptor
LY377604 is a human β 3 -adrenergic receptor agonist with an EC 50 of 2.4 nM and also a β 1 - and β 2 -adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β 1 adrenergic receptor or the human β 2 adrenergic receptor.
Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.