1905453-18-0
物理化学性质
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | Water : 17 mg/mL (100.51 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble) |
| 酸度系数(pKa) | 9.32±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
1905453-18-0价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-103236 | 1905453-18-0 NSC232003 | 1905453-18-0 | 1mg | 790元 |
| 2024/11/08 | HY-103236 | 1905453-18-0 NSC232003 | 1905453-18-0 | 10mM * 1mLin Water | 1674元 |
| 2024/11/08 | HY-103236 | 1905453-18-0 NSC232003 | 1905453-18-0 | 5mg | 1850元 |
常见问题列表
UHRF1
NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pK a of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA.