1638750-95-4
基本信息
ADU-S100二钠盐
MIW815 disodium salt
ADU-S100 disodium salt
ML RR-S2 CDA Sodium Salt
ML RR-S2 CDA disodium salt
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
物理化学性质
| 储存条件 | -20°C储存 |
| 形态 | Solid |
| 颜色 | White to off-white |
| 水溶解性 | Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH) |
ADU-S100 DISODIUM SALT价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-12885A | ADU-S100 DISODIUM SALT ADU-S100 disodium salt | 1638750-95-4 | 1mg | 3300元 |
| 2023/03/20 | HY-12885A | ADU-S100 DISODIUM SALT ADU-S100 disodium salt | 1638750-95-4 | 5mg | 12000元 |
| 2023/03/20 | HY-12885A | ADU-S100 DISODIUM SALT ADU-S100 disodium salt | 1638750-95-4 | 10mg | 20000元 |
常见问题列表
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.