156215-70-2
中文名称
化合物 T28780
英文名称
3-Quinolinecarboxylic acid, 7-(7-amino-5-azaspiro[2.4]hept-5-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-
CAS
156215-70-2
分子式
C20H22FN3O4
分子量
387.4
MOL 文件
156215-70-2.mol
结构式
基本信息
中文别名
化合物 T28780
英文别名
Sinafloxacin Mesylate
3-Quinolinecarboxylic acid, 7-(7-amino-5-azaspiro[2.4]hept-5-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-
3-Quinolinecarboxylic acid, 7-(7-amino-5-azaspiro[2.4]hept-5-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-
物理化学性质
| 沸点 | 630.9±55.0 °C(Predicted) |
| 密度 | 1.51±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 6.42±0.50(Predicted) |
应用领域
用途一
Sinafloxacin Mesylate is a quinolone antibiotic potentially for the treatment of bacterial infections. There is a strong interaction between sinafloxacin and BSA. From thermodynamic coordination it can be judged that the binding force between sinafloxacin and BSA is mainly electro-static force. The effect of sinafloxacin on the conformation of BSA was analyzed by synchronous fluorescence spectrometry and three-dimensional fluorescence spectrometry. The emission maximum of tyrosine residues does not show a significant shift, while the small blue shift of tryptophan residues indicates that the hydrophobicity of microenvironment was increased. In addition, in the plasma, there are some metal ions, which can participate in many important vital actions and affect the reactions of the drugs with the serum albumins.
常见问题列表
概述
Sinafloxacin free base 是一种喹诺酮类抗生素。