14930-96-2
基本信息
松胞菌素B
细胞松驰素B
细胞松弛素B
细胞松弛素 B
细胞分裂抑素B
细胞松弛素 B 来源于长蠕孢菌
CYTOCHALASIN B 细胞松弛素B
细胞松弛素 B 来源于DRECHSLERA DEMATIOIDEA
-23-one
cytochalasin
CYTOCHALACINB
CYTOCHALICINB
CYTOCHALASIN B
CYTOCHALASIN B(RG)
(7s,13e,16r,20r,21e)-0-phenyl
CYTOCHALASIN B SYNTHETIC >97%
9r,12as,13s,15s,15as,16as,18as)-5
物理化学性质
熔点 | 218-223 °C |
熔点 | 218-223 °C |
沸点 | 577.96°C (rough estimate) |
密度 | 1.1490 (rough estimate) |
折射率 | 1.6290 (estimate) |
闪点 | 85℃ |
储存条件 | −20°C |
储存条件 | -20°C |
溶解度 | ethanol: 20 mg/mL |
溶解度 | 乙醇:20 mg/mL |
酸度系数(pKa) | 13.60±0.70(Predicted) |
形态 | powder |
颜色 | white |
Merck | 13,2819 |
BRN | 1096207 |
稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 1 个月。 |
InChIKey | UXVDBQLLXVKPRS-UZBFCAAUSA-N |
LogP | 3.370 |
EPA化学物质信息 | 2H-Oxacyclotetradecino[ 2,3-d]isoindole-2,18(5H)- dione, 6,7,8,9,10,12a,13,14,15,15a, 16,17-dodecahydro-5,13-dihydroxy- 9,15-dimethyl-14-methylene- 16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S, 15aS,16S,18aS)-(14930-96-2) |
安全数据
危险性符号(GHS) | GHS06,GHS08 |
警示词 | 危险 |
危险性描述 | H300+H310+H330-H361 |
防范说明 | P201-P202-P260-P280-P302+P352+P310-P304+P340+P310 |
危险品标志 | T+,T |
危险类别码 | 26/27/28-63-23/24/25 |
危险类别码 | 26/27/28-63-23/24/25 |
安全说明 | 28-36/37-45 |
安全说明 | 28-36/37-45 |
危险品运输编号 | UN 1544 6.1/PG 2 |
危险品运输编号 | UN 1544 6.1/PG 2 |
WGK Germany | 3 |
WGK Germany | 3 |
RTECS号 | RO0205000 |
F | 10 |
危险等级 | 6.1(a) |
包装类别 | I |
海关编码 | 29349990 |
毒害物质数据 | 14930-96-2(Hazardous Substances Data) |
毒性 | LD50 intraperitoneal in mouse: 30mg/kg |
应用领域
常见问题列表
细胞松弛素B在细胞内同微丝的正端结合, 并引起F-肌动蛋白解聚,阻断亚基的进一步聚合。当将细胞松弛素加入到活细胞后,肌动蛋白纤维骨架消失,使动物细胞的各种活动瘫痪, 包括细胞的移动、吞噬作用、胞质分裂等。
Kd: 2.2 nM (F-actin, with Mg 2+ ), 1.4 nM (F-actin, with Mg 2+ /K + )
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with K d s of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl 2 (2 mM) or MgCl 2 (2 mM) plus KCl, respectively. Cytochalasin B (0.1-10 μM) shows inhibitory effect on multiple murine cancer cell lines, with IC 50 s of 2.56 μM (M109c), 10.46 μM (B16BL6), 105.5 μM (P388/ADR), 51.9 μM (P388/S) and IC 80 s of 12.23 μM (M109c), 44.86 μM (B16BL6), 188.4 μM (P388/ADR), 84.1 μM (P388/S) after treatment for 3 h, with IC 50 s of 0.25 μM (M109c), 0.37 μM (B16F10), 0.87 μM (B16BL6), and IC 80 s of 0.75 μM (M109c), 1.21 μM (B16F10), 10.41 μM (B16BL6) after treatment for 4 days. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments. In addition, Cytochalasin B accelerates the transformation from F-actin to G-actin, lowering the content of F-actin and significantly increasing G-actin bands during postmortem conditioning.
Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort.
细胞松弛素 B价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/11/11 | XW149309624 | 细胞松弛素B cytochalasin b from drechslera dematioidea;phomin | 14930-96-2 | 1MG | 791元 |
2024/11/08 | 22809 | 细胞松弛素B Cytochalasin B | 14930-96-2 | 1mg | 1235元 |
2024/11/08 | 22809 | 细胞松弛素B Cytochalasin B | 14930-96-2 | 5mg | 3939元 |