145854-59-7
基本信息
MASTOPARAN 7
INLKALAALAKALL-NH2
Mastoparan-7, ≥97% (HPLC)
MASTOPARAN 7 SYNTHETIC >98%
mastoparan from polistes jadwagae
MAS 7 - CAS 145854-59-7 - Calbiochem
Mastoparan-7 >=97% (HPLC), lyophilized powder
19: PN: WO2010069074 SEQID: 17 claimed protein
ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
物理化学性质
| 沸点 | 1649.9±65.0 °C(Predicted) |
| 密度 | 1.154±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 酸度系数(pKa) | 13.43±0.46(Predicted) |
| 形态 | lyophilized powder |
| 颜色 | White to off-white |
| 水溶解性 | water: 5mg/mL |
| 序列 | Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH2 |
安全数据
| 危险性符号(GHS) |   GHS07,GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H317-H334 |
| 防范说明 | P261-P280-P342+P311 |
| WGK Germany | 3 |
常见问题列表
胡蜂蜂毒肽 7是黃蜂毒素中的一种多肽，序列中含有14个氨基酸，是 mastoparan 的结构类似物，是异源三聚体 Gi 蛋白及其下游效应物的活化剂。胡蜂毒肽是胡蜂蜂毒中最丰富的肽家族，是一种具有14个氨基酸残基的膜活性两亲肽。在低浓度下能导致组胺释放，造成炎症和水肿。它富含形成两亲螺旋结构的疏水和碱性残基（阳离子残基），后者具有在膜上形成孔的能力，可插入到膜双分子层中导致膜的不稳定及溶解或直接影响胞质上的G蛋白来干扰跨膜信号，刺激磷脂酶，转移线粒体和肌质网的Ca²⁺，导致细胞直接死亡或凋亡。
Mas7 (Mastoparan 7) produces several biological effects in different cell types. The effect of Mas7 on endogenous mono-ADP-ribosyltransferase activity is in the micromolar range with a maximal activation of 205% over the basal. In pertussis treated plasma membranes, it is found that the effect of Mas7 on endogenous mono-ADP-ribosyltransferase is partially blocked, which suggests the involvement of G-proteins, such as Gi or G0.
Mas7 is a basic tetradecapeptide isolated from isp venom, which activates guanine nucleotide-binding regulatory proteins (G-proteins) and stimulates apoptosis. In smooth muscle cells, Mas7 leads to an increase in the perfusion pressure. Vascular contraction is induced by Mas7. The vasoconstriction triggered by mas-7 exhibited a slower increase compared to that simulated by phenylephrine or vasopressin.
Exposure of hippocampal neurons to a low dose of Mas-7 increases dendritic spine density and spine head width in a time-dependent manner. Additionally, Mas-7 enhances postsynaptic density protein-95 (PSD-95) clustering in neurites and activates Gαo signaling, increasing the intracellular Ca
2+
concentration.
胡蜂蜂毒肽 7价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-P0258 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 Mas7 | 145854-59-7 | 1mg | 900元 |
| 2024/01/25 | HY-P0258 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 Mas7 | 145854-59-7 | 5mg | 3600元 |
| 2024/01/25 | HY-P0258 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 Mas7 | 145854-59-7 | 10mg | 5600元 |