1445605-23-1
基本信息
(1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二酰胺
Lu AF21934
LuAF21934, >98%
LU-AF 21934
LU AF 21934
LU AF-21934
LU AF 21934
LU-AF21934
LU-AF-21934
(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide
1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)-
2-PYRIMIDINAMINE,4-METHYL-N-[5-METHYL-4-(1H-PYRAZOL-4-YL)-2-THIAZOLYL]-, >98%
物理化学性质
| 沸点 | 577.6±50.0 °C(Predicted) |
| 密度 | 1.386±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | ≥31.5 mg/mL in DMSO; insoluble in H2O; ≥5.03 mg/mL in EtOH with ultrasonic |
| 酸度系数(pKa) | 13.23±0.70(Predicted) |
| 形态 | 固体 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319 |
| 防范说明 | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
(1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-100366 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 Lu AF21934 | 1445605-23-1 | 5mg | 850元 |
| 2024/01/25 | HY-100366 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 Lu AF21934 | 1445605-23-1 | 10mM * 1mLin DMSO | 935元 |
| 2024/01/25 | HY-100366 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 Lu AF21934 | 1445605-23-1 | 10mg | 1450元 |
常见问题列表
|
mGlu4 Receptor 500 nM (EC 50 ) |
Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI.