14417-88-0
基本信息
化合物 T16036
CS-2397
Melinamide
DL-a-Methylbenzyl linoleamide
N-(a-Methylbenzyl)linoleamide
N-(2-methylbenzyl)linoleamide
N-(α-Methylbenzyl)linoleamide
DL-N-(a-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide
物理化学性质
| 熔点 | <4° |
| 沸点 | bp0.03 200-215°; bp0.07 200-204° |
| 密度 | 0.928±0.06 g/cm3(Predicted) |
| 折射率 | nD23 1.5050; nD30 1.4863 |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 15.56±0.46(Predicted) |
| 形态 | Oil |
| 颜色 | Colorless to light yellow |
| CAS 数据库 | 14417-88-0 |
常见问题列表
IC50: 20.9 μM (cholesterol)
DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide.
Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment.