1420-08-2
英文名称
desacetamidocolchicine
CAS
1420-08-2
分子式
C20H22O5
分子量
342.39
MOL 文件
1420-08-2.mol
结构式
基本信息
英文别名
Deacetamidocolchicine
desacetamidocolchicine
Deacetylaminocolchicine
Desacetylaminocolchicine
6,7-Dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-
desacetamidocolchicine
Deacetylaminocolchicine
Desacetylaminocolchicine
6,7-Dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-
应用领域
用途一
Desacetamidocolchicine (DAAC) is a colchicine analogue that lacks the acetamido side chain in the ring-B of colchicine. Unlike colchicine, it binds to tubulin very quickly, and yet it has powerful antimitotic properties. It has been demonstrated that the beta-tubulin isoforms differ significantly in their interactions with colchicine.