1404091-23-1
物理化学性质
| 沸点 | 643.5±55.0 °C(Predicted) |
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.40±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
1404091-23-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 1mg | 1500元 |
| 2025/02/08 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 5mg | 4500元 |
| 2024/08/19 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 10mg | 7500元 |
常见问题列表
NucPE1 features two major visible region absorptions (λ abs =468 nm, ε=27,300 M -1 cm -1 ; λ abs =490 nm, ε=26,000 M -1 cm -1 ) and a weak emission (λ em =530 nm, Φ=0.117). Reaction of NucPE1 with H 2 O 2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M -1 cm -1 ) with enhanced emission (λ em =530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans , where it can respond to subcellular changes in H 2 O 2 fluxes.
NucPE1 maintains the ability to selectively target nuclei in vivo . NucPE1 imaging reveals a reduction in nuclear H 2 O 2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.