138489-18-6
基本信息
双吲哚马来酰亚胺 IX 甲烷磺酸盐
MK-7123, PS-291822
RO-31-8220
Ro31-8220MsOH
Ro 31-8220 Mesylat
Ro 31-8220/Ro318220
RO-31-8220 USP/EP/BP
BisindolylMaleiMide IX Mesylate
BISINDOLYLMALEIMIDE IX, METHANESULFONATE
Ro-31-8220 - CAS 138489-18-6 - Calbiochem
Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
物理化学性质
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM) DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM) Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM) |
| 形态 | 红色固体 |
| 颜色 | 红色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | water: 1mg/mL DMSO: 100mg/mL |
| InChIKey | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| SMILES | CS(O)(=O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(N)=N)c4ccccc34)c5ccccc15 |
安全数据
| WGK Germany | WGK 3 |
| 海关编码 | 2933790090 |
| 存储类别 | 11 - Combustible Solids |
RO-31-8220价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-13866R | RO-31-8220 Ro 31-8220 mesylate (Standard) | 138489-18-6 | 5 mg | 2000元 |
| 2026/09/15 | HY-13866 | RO-31-8220 Ro 31-8220 mesylate | 138489-18-6 | 1 mg | 336元 |
| 2026/09/15 | HY-13866R | RO-31-8220 Ro 31-8220 mesylate (Standard) | 138489-18-6 | 10 mg | 3000元 |
常见问题列表
|
PKC-α 5 nM (IC 50 ) |
PKC-βI 24 nM (IC 50 ) |
PKC-βII 14 nM (IC 50 ) |
PKC-γ 27 nM (IC 50 ) |
PKC-ε 24 nM (IC 50 ) |
Rat Brain PKC 23 nM (IC 50 ) |
MAPKAP-K1b 3 nM (IC 50 ) |
MSK1 8 nM (IC 50 ) |
S6K1 15 nM (IC 50 ) |
GSK3β 38 nM (IC 50 ) |
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC 50 s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Moreover, Ro 31-8220 directly suppresses voltage-dependent Na + channels. Ro 31-8220 (1 μM) is neuroprotective against paraoxon-induced neuronal cell death in cerebellar granule neurons, blocks paraoxon-induced caspase-3 activity, and reduces the paraoxon-induced increase in phospho-PKC pan levels.
Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP −/− mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change.