13153-27-0
基本信息
NBTGR
6-(4-nitrobenzylthio)guanosine
S-(P-NITROBENZYL)-6-THIOGUANOSINE
S-(4-NITROBENZYL)-6-THIOGUANOSINE
S-(4-Nitrobenzyl)-6-thioguanosine,99%
2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN
NBTG, NBTGR, 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
物理化学性质
| 熔点 | 203-205 °C |
| 沸点 | 858.3±75.0 °C(Predicted) |
| 密度 | 1.3888 (rough estimate) |
| 折射率 | 1.7000 (estimate) |
| 储存条件 | 0-6°C |
| 溶解度 | Soluble in DMSO |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 形态 | Solid |
| 颜色 | Off-white to yellow |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| 安全说明 | 24/25 |
常见问题列表
Ki: 70 nM (adenosine uptake)
A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides.